| Criteria | Selection | Familial Homozygous 10958R (Fortnightly) 11193D (Monthly) |
Familial Heterozygous 11484K (Fortnightly) 11485L (Monthly) |
Non-Familial 11484K (Fortnightly) 11485L (Monthly) |
|---|---|---|---|---|
| Treatment in conjunction with dietary therapy and exercise | ||||
| Genetic testing showing Familial Homozygous OR Dutch lipid 7 or more |
NA | NA | ||
| Genetic testing showing familial heterozygous OR Dutch lipid 6 or more |
NA | NA | ||
| Has been treated with maximal statin dose (or max tolerated) for at least 12 weeks OR Clinical important adverse events with Rosuvastatin and Atorvastatin OR Contraindication to Statin (defined on TGA-approved PI) |
||||
| LDL in Excess of 1.8 on maximal treratment | NA | |||
| LDL in Excess of 1.8 on maximal treatment, with "Symptomatic atherosclerotic CV Disease"* OR LDL greater than 5 on treatment |
NA | NA | ||
| Treated with Ezetimibe for at least 12 consecutive weeks in conjunction with a statin | NA | |||
| Symptomatic atherosclerotic CV Disease * | NA | NA | ||
| • Atherosclerotic disease in two or more vascular territories (coronary, cerebrovascular or peripheral vascular territories); OR • Severe multi-vessel coronary heart disease (defined as at least 50% stenosis in at least two large vessels); OR • Had at least two major cardiovascular events (i.e. myocardial infarction, unstable angina, stroke or unplanned revascularisation) in the previous 5 years; OR • Diabetes mellitus with microalbuminuria; OR • Diabetes mellitus and be aged 60 years or more; OR • Aboriginal or Torres Strait Islander with diabetes mellitus; OR • Thrombolysis in Myocardial Infarction (TIMI) risk score for secondary prevention of 4 or higher |
NA | NA | ||
| Results: | - |
• Prior myocardial infarction; OR
• Prior revascularisation procedure; OR
• Angina associated with demonstrated significant coronary artery disease (50% or greater stenosis in 1 or more coronary arteries on imaging), or positive functional testing (e.g. myocardial perfusion scanning or stress echocardiography)); or
• Prior ischaemic stroke; OR
• Prior revascularisation procedure; OR
• Transient ischaemic attack associated with 50% or greater stenosis in 1 or more cerebral arteries on imaging)
• Prior acute ischaemic event due to atherosclerosis; OR
• Prior revascularisation procedure; OR
• Symptoms of ischaemia with evidence of significant peripheral artery disease (50% or greater stenosis in 1 or more peripheral arteries on imaging)